Ultrasound- and NIR-Responsive Polydextran/Black TiO₂ Nanocomposite Hydrogels for Triple-Modal Antibacterial Therapy.

ABSTRACT: Titanium dioxide (TiO₂)-containing nanocomposite hydrogels have shown great promise in biomedical applications, where TiO₂ nanoparticles serve as sensitizers to generate reactive oxygen species (ROS) in sonodynamic therapy (SDT) and photodynamic therapy (PDT). Nevertheless, the limited bandgap of TiO₂ nanoparticles restricts activation to ultraviolet light, and the recombination of electron-hole pairs diminishes ROS production efficiency. Here, an innovative TiO₂-containing nanocomposite hydrogel is developed by incorporating black TiO₂ (bTiO₂) nanoparticles into a hydrazone-cross-linked polymeric network of polydextran aldehyde (PDA) and polydextran hydrazide (PDH). Particularly, bTiO₂ nanoparticles are further f

SUBMITTER: Wang TY 

PROVIDER: S-EPMC12412109 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature