Different physiologic biomechanical metrics correlate with aortic diameter increases in normal maturation compared to aneurysm progression in mice.

ABSTRACT: Thoracic aortic aneurysm (TAA) is the major cardiovascular manifestation of Marfan Syndrome (MFS), a connective tissue disorder caused by mutations in fibrillin-1. Aneurysmal dilation usually occurs in the ascending aorta (ASC) in MFS, but structural and mechanical changes are detectable throughout the arterial tree that may lead to dissection and rupture. Clinical management includes measuring ASC diameter and/or growth rate but does not typically include other regions of the thoracic aorta and dissection in the descending aorta (DSC) can occur after surgical replacement of the ASC. In severe forms of MFS, dilation forms concomitantly with aortic maturation, so it can be difficult to separate normal and pathologic changes in diameter. We used Fbn1^mgR/mgR (MU) (a model of severe

SUBMITTER: Wu Y 

PROVIDER: S-EPMC12412189 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature