Validation of a new non-invasive predictive score (KASAI) for primary aldosteronism subtyping.

ABSTRACT:

Introduction

Adrenal venous sampling (AVS) is considered the gold standard test for primary aldosteronism (PA) subtyping. Considering the limited availability of this challenging procedure, we propose a noninvasive score predicting unilateral (UPA) or bilateral (BPA) form of PA in order to reduce the need for AVS.

Material and methods

The score was retrospectively developed from a cohort of 72 patients who underwent AVS (21 patients with BPA and 51 with UPA) at Cliniques Universitaires Saint Luc between 1993 and 2021. Another multicenter cohort of 130 patients who underwent AVS (67 patients with BPA and 63 with UPA) served as external validation.

Results

Four predictive parameters of UPA highlighted by logistic regression analysis were integrated into the KASAI score:

SUBMITTER: Pierman G 

PROVIDER: S-EPMC12412202 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature