Organization of the Proteostasis Network of Membraneless Organelles.

ABSTRACT: Membraneless organelles (MLOs) are dynamic macromolecular condensates that act as crucibles to modulate cellular processes. Since MLOs form in the absence of lipid membranes, it is important to understand how their effective regulation is achieved by the protein homeostasis (proteostasis) system. To address this question, a comprehensive mapping of the proteostasis network (PN) of MLOs, comprising over 220 000 protein-protein interactions is reported. This analysis reveals how regulatory proteins (PN proteins) occupy central roles in the overall protein-protein interaction network of MLOs. It is then investigated which branches of the PN are most important in the regulation of MLOs, finding that the anabolic component, which makes up ≈30% of the PN, is more closely involved than the catabo

SUBMITTER: Lim CM 

PROVIDER: S-EPMC12412463 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature