Amplifying Anti-Tumor Immune Responses via Mitochondria-Targeting Near-Infrared Photodynamic Therapy.

ABSTRACT: Pro-inflammatory photodynamic therapy (PDT) holds immense potential to ignite robust and long-lasting systemic anti-tumor immune responses. However, the limited penetration depth of conventional ultra violet (UV)-visible irradiation and the tumor hypoxia microenvironment significantly constrain the efficacy of immune-regulatory PDT. Here, a mitochondria-targeting enhanced nanoplatform (NZ_@TG) is reported, activated by near-infrared (NIR) light-driven PDT, to address these challenges and amplify systemic anti-tumor immunity. This nanoplatform employs an interfacial lanthanide-organic triplet photosensation mechanism to realize localized oxidative damage of oxygen-rich mitochondria under NIR irradiation. Simultaneously, the exacerbated hypoxia induced by PDT activates a TH302 prod

SUBMITTER: Li CA 

PROVIDER: S-EPMC12412487 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature