Near-Infrared Afterglow Imaging-Guided Surgical Resection and Synergistic Photodynamic-Chemo Therapy of Breast Cancer.

ABSTRACT: The recurrence rate of cancer following surgical procedures is markedly affected by the degree of tumor removal. During the operation, tumor-targeted imaging is of crucial significance as it assists surgeons in attaining the most comprehensive tumor excision. Herein, a theranostic platform (CDSP NPs) is developed through the assembly of carbon dots (CDs) with paclitaxel prodrugs. CDSP NPs can be utilized for near-infrared (NIR) afterglow imaging-guided precise removal of breast cancer, featuring a long lifetime (>2 h), deep tissue penetration (>13 mm), and a high signal-to-noise ratio (SNR, 103.9), thereby effectively preventing cancer recurrence. Additionally, the combined treatment of photodynamic therapy (PDT) and chemotherapy substantially enhances tumor regression, demonstrating the t

SUBMITTER: Li Z 

PROVIDER: S-EPMC12412500 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature