BMSC-NFMC Model for Vascular Regulation and Interface Integration in Osteochondral Regeneration.

ABSTRACT: The core challenge in osteochondral tissue engineering is achieving the dual objectives of precise vascularization regulation and effective interface integration. Current tissue-engineering strategies have limitations in addressing these challenges. This study has regulated BMSC differentiation by optimizing the GT/PCL ratio and topological structure of nanofibrous materials, systematically comparing three different materials (r5G5P, a5G5P, and a7G3P), and employing a "rolling and folding" method in order to construct BMSC-NFMC composite structures. This approach achieves effective vascular isolation between the bone and cartilage layers. After implantation in nude mice, the a5G5P group exhibits distinct natural osteochondral tissue structural characteristics, which become more stable afte

SUBMITTER: Zhou Q 

PROVIDER: S-EPMC12412503 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature