Dopamine D1 Receptor Contributes to Glucocorticoid-Associated Osteonecrosis of Femoral Head Protection Through the ATF3/CHOP Axis to Inhibit Osteoblastic Apoptosis.

ABSTRACT: The nervous system plays a pivotal regulatory role in the maintenance of bone homeostasis, and the protective effects of dopamine and its receptors on bone metabolism are emerging. Despite these protective roles, the functional contribution of dopaminergic signaling, particularly through specific receptor subtypes, remains unexplored in glucocorticoid (GC)-associated osteonecrosis of the femoral head (ONFH) pathogenesis. Here, the dopamine D1 receptor (DRD1), a G protein-coupled receptor with few identified bone-related functions, is identified as a positive regulator of GC-induced apoptosis. The dopamine levels in the serum of GC-associated ONFH patients are significantly lower than those in the normal population. The protein and gene expression levels of DRD1 and the number of DRD1-posit

SUBMITTER: Zheng K 

PROVIDER: S-EPMC12412510 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature