Phosphorylation-Dependent Stabilization of Collaborator of ARF (CARF) Suppresses Lymphoma Cell Proliferation.

ABSTRACT: Uncontrolled cell proliferation drives tumorigenesis and malignant progression, making cell cycle regulation a promising strategy for cancer therapy. Phosphorylation plays pivotal roles in cancer initiation and metastasis by regulating the cancer-related proteins. Identifying key phosphorylation sites is essential for inhibiting tumor cell proliferation and optimizing therapy strategy. Here, this study reveals the strong association of oncogene Collaborator of ARF (CARF), a cell-division regulator interacting with p53, with prognosis and survival of lymphoma patients through pan-cancer analysis. In addition, this study finds that mammalian CARF shares homology with Kip-Related Protein6 (KRP6), a cell cycle inhibitor from higher plant Arabidopsis. KRP6 is regulated by casein kinase1 via pho

SUBMITTER: Qu L 

PROVIDER: S-EPMC12412514 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature