Multimodal Investigation of Angiogenesis and Its Prevention by Small Compounds in a Zebrafish Cancer Model.

ABSTRACT: Aberrant angiogenesis is a hallmark of many pathologies. In cancer, tumor growth and metastasis strongly depend on angiogenesis triggered by neoplastic cells. Antiangiogenic therapies are approved to treat different kinds of cancer. However, the success of these treatments is so far limited as some patients do not respond at all and others develop resistances. Thus, a deeper understanding of the mechanisms driving tumor angiogenesis and the variations in tumor vessels is crucial. Optical coherence tomography angiography (OCTA) is a fast volumetric imaging technique that provides detailed insights into tumor vascularization and perfusion of vessels in a label-free and non-invasive manner. An ultra-high resolution OCTA and confocal fluorescence imaging pipeline are developed to analyze tumor

SUBMITTER: Andreana M 

PROVIDER: S-EPMC12412526 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature