A MXene-Based Nanothermal Knife Inhibits Aggresome-Mediated Persister Formation for Preventing Dental Caries.

ABSTRACT: Early childhood caries (ECC) is one of the most common chronic diseases among children globally, affecting the health and quality of life of children. Despite various treatments, cariogenic bacteria persist, resulting in a pessimistic outlook for the prevention and treatment of ECC. A notable presence of persister cells is found within the cariogenic bacterial population, with their dormancy enabling them to evade antiseptics. Mechanistically, the downregulation of heat shock proteins (HSPs) leads to protein aggresome formation, converting active cariogenic bacteria into persisters, which confers dual defensive barriers through metabolic inertness and concomitant reduction of membrane permeability, rendering conventional antimicrobials ineffective. Given these findings, Ti₃C

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12412528 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature