WTAP Mediated m6A Modification Stabilizes PDIA3P1 and Promotes Tumor Progression Driven by Histone Lactylation in Esophageal Squamous Cell Carcinoma.

ABSTRACT: Esophageal squamous cell carcinoma (ESCC) is a common digestive tract malignant cancer with high incidence and mortality rate. Many studies have shown that long noncoding RNAs (lncRNAs are involved in the progression of various types of tumors. The lncRNA protein disulfide isomerase family A member 3 pseudogene 1 (PDIA3P1) promotes the progression of ESCC, but the molecular mechanism behind this is still unclear. In this study, PDIA3P1 is highly expressed in ESCC, produces more lactate by regulating glycolysis, and the increased lactate upregulates lactylation levels to drive tumor progression. Mechanistically, PDIA3P1 competes with miR-152-3p to prevent degradation of glucose transporter 1 (GLUT1) mRNA, and disrupts the binding between membrane-associated RING-CH 8 (MARCH8) and hexokinase

SUBMITTER: Huang T 

PROVIDER: S-EPMC12412560 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature