Deletion of NFIA Leads to Activation of S100A7 and Inflammatory Response-Induced Apoptosis of Keratinocytes in Oral Lichen Planus Progression.

ABSTRACT: S100 calcium-binding protein A7 (S100A7) has been implicated in psoriasis and other inflammatory diseases. However, the function of S100A7 in oral lichen planus (OLP), a chronic inflammatory disease, remains unclear. OLP was induced in mice by transplanting human OLP lesions into the backs of thymus-free mice, and an in vitro cell model was constructed using LPS-stimulated HaCaT cells. Gene intervention was performed using shRNA lentiviral vectors. The secretion of the pro-inflammatory factors IL-6 and TNF-α, as well as the rate of apoptosis in HaCaT cells, was also assessed. ChIP assay and dual-luciferase assay were used to validate the transcriptional regulation of S100A7 by nuclear factor 1 A-type (NFIA). The expression of S100A7 was significantly elevated in the lesion tissues of OLP-i

SUBMITTER: Tudi M 

PROVIDER: S-EPMC12412573 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature