Catalytic Hairpin Assembly-Propelled Weak-Inputs-Strong-Outputs (CP-WISO) DNA Logic Nanodevices with Orthogonal Design and Contrary Logic Responses.

ABSTRACT: Developing innovative multi-channel DNA logic systems with strong responses for weak inputs is of paramount significance for versatile molecular computing, information processing, smart biosensing, and early medical diagnostics. However, most previous works usually necessitate abundant inputs equivalent to signal probes or computing elements, and present only single-channel outputs, causing DNAs' over-consumption, limited computing functions, flexibility, and maneuverability. Herein, assisted with a catalytic-hairpin-assembly (CHA) amplifier and rational orthogonal design, the first universal weak-inputs-strong-outputs DNA system (named CP-WISO) with contrary logic responses is reported, which exhibited noticeable advantages over previous works. 1) Excellent FRET effect of dual-signal DNA

SUBMITTER: Lv X 

PROVIDER: S-EPMC12412575 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature