GHSR-Foxo1 Signaling in Macrophages Promotes Liver Fibrosis via Inflammatory Response and Hepatic Stellate Cell Activation.

ABSTRACT: Liver fibrosis is a severe liver disease directly linked to chronic inflammation, in which hepatic macrophages play a key role. Growth hormone secretagogue receptor (GHSR) is the receptor of nutrient-sensing hormone ghrelin that has essential functions in metabolism, inflammation, and wound-healing. However, the role of GHSR in liver fibrosis is unknown. This study uses a carbon tetrachloride (CCl₄)-induced liver fibrosis mouse model to investigate the role of macrophage GHSR in liver fibrosis. CCl₄ induces macrophage accumulation and inflammatory responses, noticeably increases GHSR expression in the liver. It is found that macrophage Ghsr deletion (Ghsr-MϕKO) attenuates CCl₄-induced liver fibrosis and inflammation, showing reduced hepatic monocyte-derived

SUBMITTER: Kim DM 

PROVIDER: S-EPMC12412619 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature