Robotic micromanipulation for patterned and complex organoid biofabrication.

ABSTRACT: Organoids have emerged as powerful models for recapitulating tissue physiology and pathology in biomedical research. However, the need for consistent and complex manufacturing of organoids remains a challenge. The absence of standardization and quality control of cells dispersed within extracellular matrices impedes the widespread application of organoids. Here, we introduce a micromanipulation platform that effectively constrains cell distribution to enable patterned and complex organoid biofabrication. This system integrates multidimensional cell sense technology to provide real-time feedback, enabling adaptive fluid dynamics control that robustly compensates for seeding-induced nonlinear fluidic perturbations. Through this closed-loop control, the micromanipulation platform effectively

SUBMITTER: Tong M 

PROVIDER: S-EPMC12412664 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature