A systematic review and modelling insights of factors impacting measles vaccine effectiveness, efficacy and immunogenicity.

ABSTRACT:

Introduction

Outbreaks of measles have been frequently reported despite the availability of an effective vaccine. In this systematic review we examine the potential factors that could impact the effectiveness, efficacy and immunogenicity of the measles vaccine (MV) in children.

Methods

We conducted a literature search using PubMed and Google Scholar for primary articles published between January 2010 and April 2025. Articles reporting the effectiveness, efficacy or immunogenicity of MV in children aged 0-15 years were included. Additionally, we use regression analysis on data available from few cohort studies in India and epidemiological modelling simulations to assess the effect of factors on vaccine effectiveness (VE), efficacy and immunogenicity.

Results

Overall, 4

SUBMITTER: Ghosh S 

PROVIDER: S-EPMC12412780 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature