Allostatic Load Mediates Associations Between Race and Ethnicity and Hypertensive Disorders of Pregnancy.

ABSTRACT:

Objective

To evaluate whether chronic stress exposure, measured by allostatic load (a biological measure of chronic stress embodiment, including stressors exacerbated by structural inequities [eg, structural racism]) and patient-reported perceived stress in the first trimester of pregnancy, mediates the association between self-identified race and ethnicity and hypertensive disorders of pregnancy (HDP).

Methods

This was a secondary analysis of data from nuMoM2b (Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be), a large prospective cohort study. We evaluated self-identified race and ethnicity as an independent variable (non-Hispanic Black, Hispanic, Asian, non-Hispanic White), and our outcome of interest was HDP (ie, gestational hypertension, preeclampsia or ec

SUBMITTER: Ray M 

PROVIDER: S-EPMC12412905 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature