The putative AraC-type transcriptional regulator STM1082 facilitates <i>Salmonella</i> pathogenicity through modulation of intestinal invasion and intracellular replication.

ABSTRACT: Salmonella is a food-borne zoonotic pathogen that causes human gastroenteritis and potentially fatal systemic infections. The invasion of intestinal epithelial cells and the survival and replication within host macrophages are essential for the intestinal and systemic infections caused by Salmonella, respectively. To precisely regulate the expression of virulence-related genes, Salmonella relies on a series of regulatory proteins. In this study, we identified STM1082, a putative AraC-type transcriptional regulator, as a new virulence activator in Salmonella. The expression of the STM1082 gene is up-regulated when Salmonella invades HeLa epithelial cells and replicates within RAW264.7 macrophages. Mutation of STM1082 impaired the ability of <

SUBMITTER: Ma S 

PROVIDER: S-EPMC12413039 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature