The <i>Mycobacterium tuberculosis</i> complex pangenome is small and shaped by sub-lineage-specific regions of difference.

ABSTRACT: The Mycobacterium tuberculosis complex (MTBC) is a group of bacteria causing tuberculosis (TB) in humans and animals. Understanding MTBC genetic diversity is crucial for insights into its adaptation and traits related to survival, virulence, and antibiotic resistance. While it is known that within-MTBC diversity is characterised by large deletions found only in certain lineages (regions of difference [RDs]), a comprehensive pangenomic analysis incorporating both coding and non-coding regions remains unexplored. We utilised a curated dataset representing various MTBC genomes, including under-represented lineages, to quantify the full diversity of the MTBC pangenome. The MTBC was found to have a small, closed pangenome with distinct genomic features and RDs both between lineages (as p

SUBMITTER: Behruznia M 

PROVIDER: S-EPMC12413193 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature