Longitudinal Multimodal Magnetic Resonance Imaging Reveals Improvement in Verbal Fluency Over Time in Moderate-to-Severe Traumatic Brain Injury.

ABSTRACT: Most individuals with moderate-to-severe diffuse axonal injury (DAI) have impaired verbal fluency (VF) capacity. Still, the relationship between brain and VF recovery post-DAI has remained mostly unknown. The aim was to assess brain changes in 13 cortical thickness regions of interest (ROIs), fractional anisotropy (FA), and free water (FW) in three language-related tracts; the VF performance at 6 and 12 months after the DAI; and whether brain changes from 3 to 6 months predict VF performance from 6- to 12-month post-DAI. Twenty-one adults with moderate and severe DAI were analyzed. Structural and diffusion data were acquired on a 3T system 3 and 6 months after the injury. The differences in cortical thickness, FA, and FW values over time were analyzed as factors for the phonemic and semant

SUBMITTER: Zaninotto AL 

PROVIDER: S-EPMC12413258 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature