Cortical α4β2-nicotinic acetylcholine receptors and cognitive decline in Parkinson's disease.

ABSTRACT: BackgroundAutopsy and in vivo molecular imaging studies suggest altered binding of the α4β2-nicotinic cholinergic receptor (α4β2-nAChR) with cognitive dysfunction in Parkinson's disease (PD).ObjectiveTo determine the relationship between cortical and hippocampal binding of the α4β2-nAChR with [¹⁸F]XTRA PET, a high-affinity radiotracer that enables quantification of α4β2-nAChR in these regions, and cognitive function in individuals with PD.MethodsIndividuals with PD (N = 32) and age-similar, controls without PD or dementia (N = 10) completed a cognitive assessment and one 90-min, [¹⁸F]XTRA PET scan. Metabolite-corrected arterial input function radioactivity time-activity curves were generated to obtain total distribution volume (V_T) across 12 regions

SUBMITTER: Mills KA 

PROVIDER: S-EPMC12413266 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature