Mitochondrial Complex Member VdNuo1 Recruits Superoxide Dismutases VdSOD2/4 to Maintain Superoxide Anion Homeostasis During Pathogenesis in Verticillium dahliae.

ABSTRACT: During oxidative phosphorylation, the leaked electrons generate superoxide anions to attack the mitochondrial inner membrane and impair mitochondrial activity. Three superoxide dismutases (SODs) are secreted to degrade host superoxide anions in Verticillium dahliae. However, the roles of mitochondrial SODs (mtSODs) in superoxide anion detoxification and in virulence are unknown in this fungus. We had previously shown that complex I VdNuo1 subunit mediates multiple biological functions and mitochondrial morphogenesis in V. dahliae. Here, we demonstrate that among the seven VdSODs of V. dahliae, only VdSOD2 and VdSOD4 were localised in the mitochondria and interact directly with VdNuo1. The VdNuo1 mutants, which exhibited mitochondrial inactivation in response to the superoxide anion inducer

SUBMITTER: Li H 

PROVIDER: S-EPMC12413312 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature