Acute kidney injury: pathogenesis and therapeutic interventions.

ABSTRACT: Acute kidney injury (AKI) is a prevalent clinical condition that is associated with unacceptably high morbidity and mortality, as well as the development of chronic kidney disease (CKD). The pathogenesis of AKI is highly complex and heterogeneous, primarily attributed to metabolic disturbances arising from the disease itself and the administration of medications related to treatment. In recent years, AKI in cancer patients is highly concerned. The emergence of AKI caused injuries and dysfunction of remote organs but also enhanced the health-care costs. It's essential for early recognition of AKI by biomarker or prediction models and further, take a timely intervention. This review aims to provide the pathophysiology of AKI covering the intricate mechanisms underpinning AKI in the dynamic c

SUBMITTER: Xu X 

PROVIDER: S-EPMC12413393 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature