DIA-based proteomics reveals anti-inflammatory role of DL-3-<i>n</i>-butylphthalide in cerebral small vessel disease-induced brain injury in hypertensive rat.

ABSTRACT:

Objectives

Excessive neuroinflammatory responses represent a key pathological mechanism in cerebral small vessel disease (CSVD). Dl-3-n-butylphthalide (NBP), a compound previously demonstrated to possess anti-inflammatory properties in ischemic stroke, was investigated for its potential therapeutic effects in a rodent model of CSVD. This study aimed to elucidate the neuroprotective mechanisms of NBP in CSVD pathogenesis.

Methods

Forty-week-old spontaneously hypertensive rats were selected as a CSVD rodent model to determine the neuroprotective effects of NBP. Cognitive ability was assessed using the Morris water maze after 28 weeks of treatment. Pathological changes in the brain tissue were observed through immunohistochemistry. Data-independent acquisition (DIA) mass

SUBMITTER: Sun J 

PROVIDER: S-EPMC12413627 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature