Assessment of Myocardial Injury Size Metrics Using Carotid Pressure Waveform: Proof-of-Concept in Coronary Occlusion/Reperfusion Rat Model.

ABSTRACT: Myocardial infarction (MI) is a leading cause of death worldwide and the most common precursor to heart failure, even after initial treatment. Precise evaluation of myocardial injury is crucial for assessing interventions and improving outcomes. Extensive evidence from both preclinical models and clinical studies demonstrates that the extent and severity of myocardial injury (i.e., myocardial infarct size, ischemic risk zone, and no-reflow area) are critical determinants of long-term outcomes post-MI. This study aims to assess whether carotid pressure waveforms, analyzed using an intrinsic frequency (IF)-machine learning (ML) approach, can accurately quantify myocardial injury sizes: myocardial infarct size, ischemic risk zone, and no-reflow area. Acute MI was induced in N = 88 Sprague-Daw

SUBMITTER: Li J 

PROVIDER: S-EPMC12413657 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature