The coupling of global brain activity and cerebrospinal fluid flow as a potential predictive marker of brain amyloid-β accumulation.

ABSTRACT:

Background

Impaired cerebrospinal fluid (CSF) clearance is thought to contribute to amyloid-β (Aβ) accumulation in Alzheimer's disease (AD). Global brain activity-CSF flow coupling (gBOLD-CSF coupling), measured through resting-state functional MRI, reflects CSF clearance capacity. A higher coupling value indicates weaker coupling. Its potential as a predictive marker for Aβ accumulation remains unclear.

Objectives

This study aims to determine whether weaker gBOLD-CSF coupling precedes Aβ accumulation in cognitively normal, Aβ-negative individuals and to explore its predictive potential for amyloid conversion.

Design

A longitudinal observational study using Alzheimer's Disease Neuroimaging Initiative (ADNI) data.

Setting

Data from ADNI-participating sites.

P

SUBMITTER: Tanaka Y 

PROVIDER: S-EPMC12413707 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature