Causal relationship and mediating role between depression and cognitive performance.

ABSTRACT:

Background

Recent studies have increasingly emphasized the robust correlation between depression and cognitive function. However, it remains unclear whether this relationship is causal or merely coincidental. To address this uncertainty, we conducted two-sample bidirectional Mendelian randomization (MR) analyses to investigate the connection between depression and cognitive performance.

Methods

We sourced genome-wide association study (GWAS) data for depression (N_SNPs=21,306,230) from the FinnGen (R10) and for cognitive performance (N_SNPs=10,049,954) from the IEU GWAS database. Causal effects employed methodologies such as Inverse variance weighted (IVW), weighted median, MR Egger, simple mode and weighted mode. Two-step analysis determined the contribu

SUBMITTER: Hao X 

PROVIDER: S-EPMC12413711 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature