New-generation antidiabetic medications and dementia risk in older adults with type 2 diabetes: A retrospective cohort study.

ABSTRACT:

Background

New-generation antidiabetic medications may have therapeutic potential for dementia, beyond their glycemic effects. However, information from observational studies exploring the association between new-generation antidiabetic use and dementia risk is limited.

Objectives

To examine the association between new-generation antidiabetic medication use and dementia risk.

Design

Retrospective cohort study using electronic health records of a large non-profit health maintenance organization.

Participants

84,798 dementia-free individuals aged ≥65y with type 2 diabetes.

Measurements

Antidiabetic medication exposure was based on purchased prescriptions and was used as a time-varying variable. Exposure periods were defined as periods in which either dipep

SUBMITTER: Cohen A 

PROVIDER: S-EPMC12413712 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature