Early detection of Alzheimer's disease using small RNAs. Results from the EPAD cohort.

ABSTRACT:

Background

Alzheimer's disease (AD) is the most common form of dementia, and early diagnosis is crucial to enable effective interventions. Currently, Alzheimer's disease is diagnosed through cognitive assessments, brain imaging and fluid biomarkers focused on determining amyloid (A) and, tau (T) protein levels as well as neurodegeneration (N) in the AT(N) framework. Prognostic biomarkers for predicting cognitive decline within the amyloid positive (Aβ+) individuals would further strengthen the framework.

Objectives

This study evaluated small RNAs as novel auxiliary biomarkers, independent of the AT(N) framework, either alone or in combination with established protein markers, for detecting the earliest cognitive decline in AD.

Design

The European Prevention of Alzheim

SUBMITTER: Sikosek T 

PROVIDER: S-EPMC12413721 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature