Tailoring multidomain intervention programs to reduce cognitive and physical decline in older adults: Examining rural-urban differences in a nationwide cluster-randomized controlled trial.

ABSTRACT:

Background

Frailty and cognitive impairment are major challenges in aging populations. Multidomain interventions targeting physical, cognitive, and nutritional health show promise; however, evidence on rural-urban differences in efficacy remains limited.

Objectives

To evaluate the impact of rural-urban disparities on the clinical efficacy of a 12-month multidomain intervention for cognitive and physical outcomes in older adults.

Design

Cluster-randomized controlled trial.

Setting

Community clusters in five cities/counties across Taiwan.

Participants

A total of 1082 adults aged ≥65 years from 40 community clusters were randomized to intervention or control groups.

Intervention

The intervention group received a 12-month program including physical ex

SUBMITTER: Ho MY 

PROVIDER: S-EPMC12413722 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature