Cerebrovascular disease in Alzheimer's disease: Brain structure as a critical mediator of cognitive decline.

ABSTRACT:

Background

The co-occurrence of Alzheimer's disease and cerebrovascular disease is increasingly prevalent in aging populations, yet the mechanisms of their interaction remain incompletely understood. This study aims to investigate the associations between CVD and AD and their composite effects on cognitive function, identifying key mediating pathways in these relationships.

Methods

Participants underwent standardized clinical evaluations, detailed neuropsychological testing, and comprehensive neuropathological examinations. Structural equation modeling with multiple mediation analyses was employed to disentangle direct and indirect effects of vascular pathology on cognition and identify key mediating pathways. Relationships between specific cognitive domain assessments and w

SUBMITTER: Tang C 

PROVIDER: S-EPMC12413723 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature