Deciphering pancreatobiliary intraductal oncocytic papillary neoplasms: integrative analysis of histomorphologic patterns, immunophenotypic markers, and emerging molecular biomarkers.

ABSTRACT:

Purpose

We reviewed recent advancements in the characterization of intraductal oncocytic papillary neoplasm (IOPN) of the pancreas, with a specific focus on developments in immunohistochemical markers, molecular pathology, and pathogenic mechanisms over the past ten years (2015-2024). Through comprehensive analysis of current literature, we aimed to elucidate the evolving understanding of IOPN's biological behavior and diagnostic features, while identifying potential areas for future research in this distinctive pancreatic neoplasm.

Methods

English-language articles on IOPN were searched from Pubmed from the first report of IOPN of the pancreas in 2015 to 2024.

Results

Significant advancements have been achieved in IOPN research. Molecular investigations discover seve

SUBMITTER: Qian Y 

PROVIDER: S-EPMC12413747 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature