Serum-derived exomiR-188-3p is a promising novel biomarker for early-stage ovarian cancer.

ABSTRACT:

Background

The exosomal microRNAs (exomiRNAs) are promising novel biomarkers for clinical detection and prognosis assessment of human cancers. The aim of this study was to identify potential exomiRNAs as biomarkers in ovarian cancer (OC).

Methods

The candidate exomiRNAs were screened by analysis of GSE235525, GSE239685, and GSE216150 datasets and further validated in exosome samples from the serum of 61 patients with OC and OC cell lines by qPCR. The correlations between exomiRNAs expression and clinicopathological features of OC patients were assessed, and Kaplan-Meier survival and receiver operating characteristic curves were employed to analyze the prognostic and diagnostic values.

Results

We found that exomiR-188-3p expression was downregulated in patients with OC

SUBMITTER: Wang M 

PROVIDER: S-EPMC12413797 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature