Risk factors for adverse pregnancy outcomes in systemic lupus erythematosus: a meta-analysis and systemic review.

ABSTRACT:

Purpose

Systemic lupus erythematosus (SLE) is a prominent autoimmune disease highly linked to adverse pregnancy outcomes (APOs). Previous research on the risk factors for APOs in SLE pregnancies has been limited by regional constraints or inadequate sample sizes. Comprehensive systematic reviews on this topic remain scarce. To address these research gaps, we conducted a rigorous meta-analysis and systematic review to elucidate the risk factors for APOs in SLE pregnancies.

Methods

PubMed, Embase, Web of Science, and the Cochrane Library systematically searched for articles on risk factors for APOs in SLE pregnancy from initiation to March 25, 2025. Pooled odds ratios (ORs) were calculated using fixed-effect or random-effects models based on heterogeneity (I²). Egge

SUBMITTER: Sun C 

PROVIDER: S-EPMC12414046 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature