Oxidative stress biomarkers in fetal growth restriction: a systematic review and meta-analysis.

ABSTRACT:

Purpose

Fetal growth restriction (FGR) affects about 10% of pregnancies and is linked to higher risks of perinatal mortality and long-term health issues, largely due to placental insufficiency and oxidative stress caused by hypoxia and inflammation. This study examines key oxidative stress biomarkers to assess significant differences in FGR versus appropriate for gestational age (AGA) neonates.

Methods

This meta-analysis reviewed studies up to December analyzing oxidative stress biomarkers in cord blood from FGR versus AGA newborns. Key markers analyzed included malondialdehyde (MDA), superoxide dismutase (SOD), catalase, ischemia-modified albumin (IMA), homocysteine, nitric oxide (NO), and nucleated red blood cells (NRBCs). Standardized mean differences (Cohen's d) and 95%

SUBMITTER: Li L 

PROVIDER: S-EPMC12414047 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature