Single-versus double-layer uterine closure at the time of cesarean delivery and risk of uterine scar niche: a systematic review and meta-analysis of randomized trials.

ABSTRACT:

Objective

This systematic review and meta-analysis compared single- versus double-layer uterine closure at the time of cesarean delivery.

Data sources

MEDLINE, EMBASE, Scopus, ClinicalTrials.gov, and Cochrane Central Register of Controlled Trials were searched from inception until May 2024.

Study eligibility criteria

We included only randomized controlled trials (RTSs) that compared single-layer versus double-layer uterine closure at the time of cesarean delivery.

Study appraisal and synthesis methods

Outcomes were analyzed using a random-effects model. Results are expressed as risk differences. The assessment of the risk of bias was performed by using the Risk of Bias 2 tool. The primary outcome was the incidence of scar defects (i.e., niche) at 6 months after

SUBMITTER: Dominoni M 

PROVIDER: S-EPMC12414086 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature