Rare phenotypes of white coat color in Simmental calves: genetic causes of syndromic forms of albinism and depigmentation.

ABSTRACT: The aim of this study was to investigate three unrelated Simmental calves with atypical white coat color, identify potential genetic causes using a trio-based whole-genome sequencing approach, and assess the prevalence of the identified variants in the breed. Several inherited alleles affecting coat color, ranging from fawn to red spotted and white-headed, have been described in Simmental cattle originating from Switzerland. However, no genetic variant has yet been associated with an almost completely white coat in this breed. Clinical examination revealed different syndromic disorders of white coat color in Simmental in all three cases, and pedigree records indicated recessive inheritance. Filtering for rare protein-changing variants revealed an independent homozygous variant that could b

SUBMITTER: Jacinto JGP 

PROVIDER: S-EPMC12414089 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature