Single frozen-thawed blastocyst derived from poor-grade Day 3 embryo is not associated with adverse neonatal outcomes: a retrospective cohort study.

ABSTRACT:

Purpose

To investigate whether single frozen-thawed blastocyst transfers derived from poor-grade Day 3 embryos influence neonatal outcomes.

Methods

This retrospective cohort study conducted in a tertiary academic medical center included all the live-born singletons (n = 3156) in vitrified-warmed single blastocyst transfer cycles from January 2013 to November 2023, which were divided into the poor-grade group (n = 2432) and the high-grade group (n = 724) based on the embryo grade on Day 3. Propensity score matching (PSM) analysis and multivariate regression analysis were used to explore the association between the embryo grade on Day 3 and neonatal outcomes.

Results

After PSM, the baseline characteristics were all comparable between the two groups. There was a signific

SUBMITTER: Li D 

PROVIDER: S-EPMC12414090 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature