The spontaneous neoantigen-specific CD4⁺ T-cell response to a growing tumor is functionally and phenotypically diverse.

ABSTRACT:

Background

CD4⁺ T cells play a critical role in the positive and negative regulation of cellular immunity through the many functional subsets they comprise. The progressive growth of immunogenic tumors which nonetheless generate mutation-specific T cells suggests that effective immune control may be avoided or suppressed at the level of the neoantigen-specific CD4⁺ T-cell response. Despite their importance, little is known about the ontogeny, architecture, and development of the CD4⁺ NeoAg-specific repertoire induced by progressively growing tumor.

Methods

We used a tetramer specific for a validated neoantigen, CTLC_H129>Q/I-A^k, to characterize the ontogeny of natural CD4⁺ T-cell responses to an aggressive and

SUBMITTER: Griswold RQ 

PROVIDER: S-EPMC12414154 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature