Identification of robust associations between admission microbiome profiles and complications of acute pancreatitis.

ABSTRACT:

Objective

Patients with acute pancreatitis show reduced gut microbiome diversity and high abundance of pathogenic bacteria compared with healthy subjects. Admission microbiome profiles are increasingly linked to severity, but methodology and study quality hamper interpretation. Our aim was to investigate whether admission microbiome analysis provides robust and reproducible associations with severity and complications of acute pancreatitis.

Methods

Patients with acute pancreatitis were prospectively enrolled from 20 Dutch hospitals (2019-2022). Admission saliva and rectal samples from 276 patients underwent 16S rDNA sequencing for microbiome profiling. Subgroups were defined based on a literature search. The microbiota endpoints (alpha- and beta-diversity, and genus abundanc

SUBMITTER: Pauw HS 

PROVIDER: S-EPMC12414194 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature