Maternal Serotonin Levels and Neurodevelopmental Severity in Autistic Children: A Partial Replication and Extension.

ABSTRACT:

Objective

The serotonin system has long been implicated in autism spectrum disorder. A previous study reported lower whole blood serotonin (WB5-HT) concentrations in the mothers of children with more severe autism. This study attempted to replicate this finding in an independent cohort.

Method

A latent profile analysis was conducted in 259 children with autism using indicator variables across autistic traits, cognition, and adaptive function. In a subgroup of 162 participants with maternal WB5-HT data, maternal WB5-HT in children with the highest severity profile was compared with maternal WB5-HT in children with other profiles, both overall and across 5 quantiles of the maternal WB5-HT distribution.

Results

A latent profile analysis solution was identified that strat

SUBMITTER: Jutla A 

PROVIDER: S-EPMC12414311 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature