Causal Analyses of Associations Between Brain Structure and Suicide Attempt in Adulthood and Late Childhood.

ABSTRACT:

Objective

Brain markers for suicide risk in adulthood may be detected during childhood and used for earlier detection and initiation of preventive interventions. Genetic instrumental variable analyses were used to determine whether there is evidence of lower brain total cortical surface area and thinner average cortical thickness (ACT) causing increased suicide risk in adults and whether lower measures of similar brain measures can cause increased risk of suicidality and related psychopathology in older children.

Method

Two-sample Mendelian randomization (MR) was used with summary statistics from genome-wide association studies for total cortical surface area, ACT, and suicide attempt in adults to test causal hypotheses. In youth ages 9 to 10 years old, a combined MR and twi

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC12414325 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature