The slow progression of Japanese encephalitis in aged mice is likely associated to B cell recruitment in the brain.

ABSTRACT: The Japanese encephalitis virus (JEV) causes Japanese encephalitis (JE), a severe disease that primarily affects children and induces significant central nervous system complications. With the widespread adoption of vaccination in children, the incidence among older individuals has increased substantially. Despite this epidemiological shift, research on JEV infection in the elderly remains limited. We established JEV infection models using both aged and young mice to explore age-related differences in pathology and underlying mechanisms. Brain tissue samples were analyzed for pathological changes and viral tropism in major cell types. To further characterize immune response variations, we conducted transcriptomic sequencing on the brain tissues following JEV infection. Aged mice exhibited

SUBMITTER: Song ZR 

PROVIDER: S-EPMC12414395 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature