DeepMobilome: predicting mobile genetic elements using sequencing reads of microbiomes.

ABSTRACT:

Motivation

Mobile genetic elements (MGEs) play an important role in facilitating the acquisition of antibiotic resistance genes (ARGs) within microbial communities, significantly impacting the evolution of antibiotic resistance. Understanding the mechanism and trajectory of ARG acquisition requires a comprehensive analysis of the ARG-carrying mobilome-a collective set of MGEs carrying ARGs. However, identifying the mobilome within complex microbiomes poses considerable challenges. Existing MGE prediction methods, designed primarily for single genomes, exhibit substantial limitations when applied to metagenomic data, often producing high false positive rates in identifying target MGEs from metagenome sequencing data.

Results

To address these challenges, we developed DeepMobil

SUBMITTER: Cho Y 

PROVIDER: S-EPMC12414478 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature