Aberrant Functional Connectivity and Brain Network Organization in High-Schizotypy Individuals: An Electroencephalography Study.

ABSTRACT:

Background and hypothesis

Oscillatory synchrony plays a crucial role in establishing functional connectivity across distinct brain regions. Within the realm of schizophrenia, suggested to be a neuropsychiatric disconnection syndrome, discernible aberrations arise in the organization of brain networks. We aim to investigate whether the resting-state functional network is already altered in healthy individuals with high schizotypy traits, highlighting the pivotal influence of brain rhythms in driving brain network alterations.

Study design

Two-minute resting-state electroencephalography recordings were conducted on healthy participants with low and high schizotypy scores. Subsequently, spectral Granger causality was used to compute functional connectivity in theta, alpha, beta

SUBMITTER: Trajkovic J 

PROVIDER: S-EPMC12414563 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature