Role of dynamical instability in QT interval variability and early afterdepolarization propensity.

ABSTRACT: Beat-to-beat variability of the QT interval (QTV) is a well-established marker of cardiac health, with increased QTV (>5 ms) often associated with a higher risk of arrhythmias. However, the underlying mechanisms contributing to this phenomenon remain poorly understood. Recently, we showed that cardiac instability is a major cause of QTV. Early afterdepolarizations (EADs) are abnormal electrical oscillations that occur during the plateau phase of the cardiac action potential (AP), often arising when the membrane potential becomes unstable. In this study, we use a physiologically detailed computational model of rabbit ventricular myocytes with stochastic ion channel gating to investigate the relationship between QTV and EAD propensity. We found that increased AP duration (APD) variability, w

SUBMITTER: Sato D 

PROVIDER: S-EPMC12414709 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature