MIND diet score and its association with metabolic dysfunction-associated steatotic liver disease and gut microbiota profiles: a cross-sectional study.

ABSTRACT:

Background

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a rising health issue linked to poor diet and gut microbiota dysbiosis. The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet, high in polyphenols and anti-inflammatory nutrients, may help protect against MASLD. This study examined how adherence to the MIND diet relates to MASLD severity, focusing on hepatic steatosis, fibrosis, insulin resistance, inflammation, and gut microbiota diversity.

Methods

A cross-sectional analysis of 450 adults with confirmed MASLD was conducted. MIND diet scores were derived from a validated FFQ. Hepatic outcomes were assessed via ultrasonography, hepatic steatosis index (HSI), controlled attenuation parameter (CAP), and fibrosis-4 (FIB-4) index.

SUBMITTER: Yang S 

PROVIDER: S-EPMC12414731 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature