Identification of lactylation-related biomarkers in osteoporosis from transcriptome and single-cell data.

ABSTRACT:

Background

Emerging evidence indicates that lactase-mediated histone lactylation can activate osteogenic gene expression and promote bone formation. However, the role of lactylation-related genes (LRGs) in osteoporosis (OP) remains unclear. This study aims to clarify the key roles of LRGs and the molecular mechanisms of related biomarkers in OP.

Methods

Three datasets (GSE7158, GSE56815, and GSE147287) and 327 LRGs were analyzed in this study. First, the biomarkers associated with OP were identified through differential gene expression analysis, machine learning algorithms, expression validation, and receiver operating characteristic (ROC) curve analysis. Subsequently, nomograms, functional enrichment analyses, immune infiltration analyses, regulatory network construction, d

SUBMITTER: Peng J 

PROVIDER: S-EPMC12414738 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature