Amphipathic Octenyl-Alanine Modified Peptides Mediate Effective siRNA Delivery.

ABSTRACT: The development of therapeutic small interfering RNAs (siRNAs) has lately gained significant momentum due to their ability to silence genes in a highly specific manner. The main obstacle withholding the wider translation of siRNA-based drug modalities is their limited half-life and poor bioavailability, especially in extra-hepatic tissues. Consequently, various drug delivery systems (DDSs) have been developed to improve the delivery of siRNAs, including short delivery peptides called cell-penetrating peptides (CPPs). In this study, we explore the potential of using alkenyl-alanine modifications to enhance the siRNA delivery efficacy with CPPs. We demonstrate on hPep peptides that incorporation of alkenyl-alanines enhances the encapsulation of siRNAs into stable nanoparticles and contribute

SUBMITTER: Lehto T 

PROVIDER: S-EPMC12414742 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature